癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD90 / Thy1 (Stromal / Mesenchymal Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone AF-9 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| IF, FC |
|---|---|
| Primary Accession | P04216 |
| Other Accession | 7070, 644697 |
| Reactivity | Human, Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | AF-9 |
| Calculated MW | 17935 Da |
| Gene ID | 7070 |
|---|---|
| Other Names | Thy-1 membrane glycoprotein, CDw90, Thy-1 antigen, CD90, THY1 |
| Application Note | IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD90 / Thy1 (Stromal / Mesenchymal Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THY1 |
|---|---|
| Function | May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Recognizes a protein of 18-35kDa, identified as CD90 (also known as Thy1). CD90 is a member of the immunoglobulin superfamily. It may contribute to inhibition of proliferation/differentiation of hematopoietic stem cells and neuron memory formation in the CNS. It consists of a single Ig domain (112 amino acids; 25-35 kDa) inserted into the cell membrane via a GPI anchor. Expressed by hematopoietic stem cells and neurons in all species studied. Its highly expressed in connective tissue and various fibroblast and stromal cell lines, expressed on all thymocytes and peripheral T cells in mice, but in humans expressed only on small % fetal thymocytes, 10-40% of CD34+ cells in bone marrow, and <1% of CD3+CD4+ lymphocytes in peripheral circulation. It is also expressed by human lymph node HEV endothelium but not other endothelia. Lastly, it is expressed by a limited number of lymphoblastoid and leukemic cell lines
REFERENCES
Beissert S et al. Impaired cutaneous immune responses in Thy-1-deficient mice. J Immunol 1998, 161(10):5296-302 | Williams, A.F., and J. Gagnon. 1982. Neuronal cell Thy-1 glycoprotein: Homology with immunoglobulin. Science 216: 696 – 703 | Fujita N et al. Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases. Exp Cell Res 1997, 232(2):400-406 | Kroczek, R.A., K.C. Gunter, R.N. Germain, and E.M. Shevach. 1986. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes. Nature 322: 181 - 184
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