癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Napsin A (Lung Adenocarcinoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone NAPSA/1239 ]
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, FC |
|---|---|
| Primary Accession | O96009 |
| Other Accession | 9476, 512843 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG, kappa |
| Clone Names | NAPSA/1239 |
| Calculated MW | 45387 Da |
| Gene ID | 9476 |
|---|---|
| Other Names | Napsin-A, 3.4.23.-, Aspartyl protease 4, ASP4, Asp 4, Napsin-1, TA01/TA02, NAPSA, NAP1, NAPA |
| Application Note | WB~~1:1000 IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Napsin A (Lung Adenocarcinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAPSA |
|---|---|
| Synonyms | NAP1, NAPA |
| Function | May be involved in processing of pneumocyte surfactant precursors. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Napsin is a pepsin-like aspartic proteinase connected with maturation of surfactant protein B.ĀThere are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.
REFERENCES
Bishop, JA et. al. Hum Pathol 41: 20-25 | Ordonez, NG 2012 Adv Anat Pathol 19: 66-73 | Ye, J et. al. Appl Immunhistochem Mol Morphol 19: 313-31
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