癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CAT Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P04040 |
| Other Accession | P04762, O62839, P24270, Q9PT92, P00432, NP_001743.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Zebrafish, Pig, Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 626CT4.3.8 |
| Calculated MW | 59756 Da |
| Antigen Region | 152-180 aa |
| Gene ID | 847 |
|---|---|
| Other Names | Catalase, CAT |
| Target/Specificity | This CAT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human CAT. |
| Dilution | WB~~ 1:1600 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CAT Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAT |
|---|---|
| Function | Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). |
| Cellular Location | Peroxisome matrix |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
REFERENCES
Banerjee, M., et al. Toxicol. Appl. Pharmacol. 249(1):47-54(2010)
Wu, S.H., et al. Clin. Chim. Acta 411 (21-22), 1705-1710 (2010) :
Liu, L., et al. J. Invest. Dermatol. 130(11):2647-2653(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Dutkiewicz, G., et al. Nephrology (Carlton) 15(5):587-591(2010)
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