癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BACH2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9BYV9 |
| Other Accession | NP_001164265.1, NP_068585.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 92537 Da |
| Antigen Region | 815-841 aa |
| Gene ID | 60468 |
|---|---|
| Other Names | Transcription regulator protein BACH2, BTB and CNC homolog 2, BACH2 |
| Target/Specificity | This BACH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 815-841 amino acids from the C-terminal region of human BACH2. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BACH2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BACH2 |
|---|---|
| Function | Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation. |
| Tissue Location | B-cell specific. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Hinks, A., et al. Ann. Rheum. Dis. (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Pierce, B.L., et al. Hum. Hered. 69(3):193-201(2010)
Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)
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¥ 1,250.00
Cat# AP10133B
