癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GDPD5 Antibody (center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WTR4 |
| Other Accession | NP_110419.5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68586 Da |
| Antigen Region | 342-369 aa |
| Gene ID | 81544 |
|---|---|
| Other Names | Glycerophosphodiester phosphodiesterase domain-containing protein 5, 31--, Glycerophosphodiester phosphodiesterase 2, GDPD5, GDE2 |
| Target/Specificity | This GDPD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-369 amino acids from the Central region of human GDPD5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GDPD5 Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GDPD5 (HGNC:28804) |
|---|---|
| Function | Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). |
| Cellular Location | Endomembrane system {ECO:0000250|UniProtKB:Q640M6}; Multi-pass membrane protein. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q640M6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q640M6}. Note=In a punctate perinuclear pattern {ECO:0000250|UniProtKB:Q640M6} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).
REFERENCES
Lang, Q., et al. Mol. Biol. Rep. 35(3):351-359(2008) Rao, M., et al. Science 309(5744):2212-2215(2005) Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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