癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GDPD5 Antibody (center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WTR4 |
| Other Accession | NP_110419.5 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68586 Da |
| Antigen Region | 342-369 aa |
| Gene ID | 81544 |
|---|---|
| Other Names | Glycerophosphodiester phosphodiesterase domain-containing protein 5, 31--, Glycerophosphodiester phosphodiesterase 2, GDPD5, GDE2 |
| Target/Specificity | This GDPD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-369 amino acids from the Central region of human GDPD5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GDPD5 Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GDPD5 (HGNC:28804) |
|---|---|
| Function | Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of various proteins, releasing them from the plasma membrane into the extracellular space (PubMed:27693046, PubMed:31932507, PubMed:33731436). Cleaves the GPI- anchor of glypican-6/GPC6, thereby positively regulating neuron differentiation in a cell-autonomous manner (PubMed:27693046, PubMed:31932507). May also hydrolyze the GPI-anchor of glypican-3/GPC3 (PubMed:27693046). Cleaves the GPI-anchor of the serine protease inhibitor RECK, leading to its inactivation (PubMed:33731436). RECK inactivation inhibits NOTCH signaling in neighboring cells and induces differentiation of spinal motor neurons (By similarity). RECK inactivation can also regulate amyloid-beta precursor protein (APP) processing by ADAM10 (PubMed:33731436). May additionally catalyze the hydrolysis of the phosphodiester bond in sn-glycerol 3-phosphocholine, potentially contributing to osmotic regulation of cellular glycerophosphocholine levels (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Cell projection, growth cone {ECO:0000250|UniProtKB:Q640M6}. Note=Colocalizes with recycling endosome as it undergoes constitutive clathrin- and dynamin-mediated internalization and recycling. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).
REFERENCES
Lang, Q., et al. Mol. Biol. Rep. 35(3):351-359(2008) Rao, M., et al. Science 309(5744):2212-2215(2005) Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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