癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IRF2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P14316 |
| Other Accession | NP_002190 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39354 Da |
| Antigen Region | 225-255 aa |
| Gene ID | 3660 |
|---|---|
| Other Names | Interferon regulatory factor 2, IRF-2, IRF2 |
| Target/Specificity | This IRF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-255 amino acids from the Central region of human IRF2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IRF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IRF2 |
|---|---|
| Function | DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN- inducible genes and regulates their expression (PubMed:39013473, PubMed:7687740). Mainly acts as a transcription repressor, repressing expression (PubMed:39013473). Also acts as an activator for several genes including H4 and IL7 (PubMed:15226432, PubMed:9540062). Constitutively binds to the ISRE promoter to activate IL7 (PubMed:15226432). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (PubMed:9540062). Antagonizes IRF1 transcriptional activation (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P23906}. Chromosome {ECO:0000250|UniProtKB:P23906} |
| Tissue Location | Expressed throughout the epithelium of the colon. Also expressed in lamina propria. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq].
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lace, M.J., et al. Virology 399(2):270-279(2010)
Masumi, A., et al. Biochem. Biophys. Res. Commun. 391(4):1623-1628(2010)
Daley, D., et al. Hum. Genet. 125(4):445-459(2009)
Dhar, D., et al. PLoS ONE 4 (9), E7049 (2009) :
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