癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GLUT2 (SLC2A2) Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, FC, E |
|---|---|
| Primary Accession | P11168 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57490 Da |
| Antigen Region | 31-60 aa |
| Gene ID | 6514 |
|---|---|
| Other Names | Solute carrier family 2, facilitated glucose transporter member 2, Glucose transporter type 2, liver, GLUT-2, SLC2A2, GLUT2 |
| Target/Specificity | This GLUT2 (SLC2A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human GLUT2 (SLC2A2). |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLUT2 (SLC2A2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC2A2 (HGNC:11006) |
|---|---|
| Function | Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Liver, insulin-producing beta cell, small intestine and kidney. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor.
REFERENCES
Freitas,H.S., Nephron Physiol 105 (3), P42-P51 (2007) Laukkanen,O., Diabetes 54 (7), 2256-2260 (2005) Roncero,I., J. Neurochem. 88 (5), 1203-1210 (2004)
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