癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TAS1R3 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q7RTX0 |
| Other Accession | NP_689414.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 93386 Da |
| Antigen Region | 229-258 aa |
| Gene ID | 83756 |
|---|---|
| Other Names | Taste receptor type 1 member 3, Sweet taste receptor T1R3, TAS1R3, T1R3, TR3 |
| Target/Specificity | This TAS1R3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-258 amino acids from the N-terminal region of human TAS1R3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TAS1R3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TAS1R3 |
|---|---|
| Synonyms | T1R3, TR3 |
| Function | Key component of the sweet and umami taste receptors (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). TAS1R1 and TAS1R3 form the umami receptor and respond to the umami taste stimulus (the taste of monosodium glutamate) (PubMed:11917125). TAS1R2 and TAS1R3 form the sweet taste receptor and recognize diverse natural and synthetic sweeteners (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359). Essential for the recognition and response to the disaccharide trehalose (PubMed:12892531). Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).
REFERENCES
Assadi-Porter, F.M., et al. J. Mol. Biol. 398(4):584-599(2010)
Assadi-Porter, F.M., et al. Biochim. Biophys. Acta 1798(2):82-86(2010)
Chen, Q.Y., et al. Am. J. Clin. Nutr. 90 (3), 770S-779S (2009) :
Chandrashekar, J., et al. Nature 444(7117):288-294(2006)
Xu, H., et al. Proc. Natl. Acad. Sci. U.S.A. 101(39):14258-14263(2004)
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