癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KDELR1/2/3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P24390, O43731, P33947 |
| Other Accession | O42580, Q8R1L4, O43731, Q7ZXS5, Q5U305, Q9CQM2, P33947, Q6PEH1, Q5ZKX9, Q2KJ37, Q569A6, Q99JH8, P33946, Q68ES4, Q6PAB8, NP_006792.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Mouse, Rat, Zebrafish, Chicken, Xenopus, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24542 Da |
| Antigen Region | 185-211 aa |
| Gene ID | 10945 |
|---|---|
| Other Names | ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, KDEL receptor 1, Putative MAPK-activating protein PM23, KDELR1, ERD21 |
| Target/Specificity | This KDELR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the C-terminal region of human KDELR1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KDELR1/2/3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDELR1 |
|---|---|
| Synonyms | ERD2.1 |
| Function | Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P33946}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33946} Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
REFERENCES
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)
Bard, F., et al. J. Biol. Chem. 278(47):46601-46606(2003)
Yamamoto, K., et al. J. Biol. Chem. 278(36):34525-34532(2003)
Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)
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