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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SEC11A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P67812 |
| Other Accession | P0C7V7, P42667, Q9R0P6, P67810, NP_055115.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20625 Da |
| Antigen Region | 95-123 aa |
| Gene ID | 23478 |
|---|---|
| Other Names | Signal peptidase complex catalytic subunit SEC11A, Endopeptidase SP18, Microsomal signal peptidase 18 kDa subunit, SPase 18 kDa subunit, SEC11 homolog A, SEC11-like protein 1, SPC18, SEC11A, SEC11L1, SPC18, SPCS4A |
| Target/Specificity | This SC11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the Central region of human SC11A. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEC11A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC11A |
|---|---|
| Synonyms | SEC11L1, SPC18, SPCS4A |
| Function | Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N- terminal signal peptides that contain a hydrophobic alpha-helix (h- region) shorter than 18-20 amino acids (PubMed:34388369). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P67811}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P67811} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).
REFERENCES
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Dodson, G., et al. Curr. Opin. Struct. Biol. 8(2):189-194(1998)
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