癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Ihh Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q80XI9 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49445 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 16147 |
|---|---|
| Other Names | Indian hedgehog |
| Target/Specificity | This Ihh antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Ihh. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Ihh Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ihh {ECO:0000313|EMBL:AAH46984.1, ECO:0000313|MGI:MGI:96533} |
|---|---|
| Function | Precursor of indian hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development. The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, indian hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N- product. Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum. Following additional lipidation, N- product acts as a morphogen, while C-product is degraded in the endoplasmic reticulum. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Secreted {ECO:0000256|ARBA:ARBA00004613} [Protein hedgehog N-product]: Cell membrane {ECO:0000256|RuleBase:RU280812}; Lipid-anchor {ECO:0000256|RuleBase:RU280812} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Ihh (Indian hedgehog) is a critical and possibly direct regulator of joint development. In its absence, distribution and function of Gdf5-expressing interzone-associated cells are abnormal.
REFERENCES
Kobayashi,T., Proc. Natl. Acad. Sci. U.S.A. 105 (6), 1949-1954 (2008) Gat-Yablonski,G.,J. Pediatr. Endocrinol. Metab. 20 (11), 1215-1222 (2007) Koyama,E., Ann. N. Y. Acad. Sci. 1116, 100-112 (2007)
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