癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
WIF1 Antibody(Human C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q9Y5W5 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41528 Da |
| Antigen Region | 347-376 aa |
| Gene ID | 11197 |
|---|---|
| Other Names | Wnt inhibitory factor 1, WIF-1, WIF1 |
| Target/Specificity | This WIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-376 amino acids from the C-terminal region of human WIF1. |
| Dilution | IHC-P-Leica~~N/A WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WIF1 Antibody(Human C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WIF1 |
|---|---|
| Function | Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. |
| Cellular Location | Secreted. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 is a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.
REFERENCES
Elston,M.S., Endocrinology 149 (3), 1235-1242 (2008)
Clement,G., Cancer Sci. 99 (1), 46-53 (2008)
Chan,S.L., Lab. Invest. 87 (7), 644-650 (2007)
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