癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADCY9 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | O60503 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 150701 Da |
| Gene ID | 115 |
|---|---|
| Other Names | Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520 |
| Dilution | WB~~ 1:1000 IHC~~1:50-1:100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADCY9 |
|---|---|
| Synonyms | KIAA0520 |
| Function | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:10987815, PubMed:12972952, PubMed:15879435, PubMed:9628827). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:10987815, PubMed:9628827) Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).
REFERENCES
Hacker B.M.,et al.Genomics 50:97-104(1998).
Small K.M.,et al.Pharmacogenetics 13:535-541(2003).
Tantisira K.G.,et al.Hum. Mol. Genet. 14:1671-1677(2005).
Paterson J.M.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Toyota T.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
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