癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ARHGEF3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NR81 |
| Other Accession | Q91X46, Q9N0A8, Q5ZLX4, NP_062455.1 |
| Reactivity | Human |
| Predicted | Chicken, Monkey, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59783 Da |
| Antigen Region | 211-240 aa |
| Gene ID | 50650 |
|---|---|
| Other Names | Rho guanine nucleotide exchange factor 3, Exchange factor found in platelets and leukemic and neuronal tissues, XPLN, ARHGEF3 |
| Target/Specificity | This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARHGEF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGEF3 |
|---|---|
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Arthur, W.T., et al. J. Biol. Chem. 277(45):42964-42972(2002)
Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
Thiesen, S., et al. Biochem. Biophys. Res. Commun. 273(1):364-369(2000)
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