癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TOMM70A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O94826 |
| Other Accession | Q75Q39, Q9CZW5 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67455 Da |
| Antigen Region | 177-205 aa |
| Gene ID | 9868 |
|---|---|
| Other Names | Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, TOMM70A, KIAA0719, TOM70 |
| Target/Specificity | This TOMM70A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-205 amino acids from the N-terminal region of human TOMM70A. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TOMM70A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TOMM70 (HGNC:11985) |
|---|---|
| Function | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812). |
| Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria.
REFERENCES
Blesa,J.R., et.al., Gene 427 (1-2), 58-64 (2008)
Chou,C.H., et.al., Mol. Biol. Cell 17 (9), 3952-3963 (2006)
Edmonson,A.M., et.al., Cell Commun. Adhes. 9 (1), 15-27 (2002)
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Cat# AP6745a
