癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ALDH3B1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P43353 |
| Other Accession | Q5XI42 |
| Reactivity | Human |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51840 Da |
| Antigen Region | 334-360 aa |
| Gene ID | 221 |
|---|---|
| Other Names | Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase 7, ALDH3B1, ALDH7 |
| Target/Specificity | This ALDH3B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-360 amino acids from the Central region of human ALDH3B1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ALDH3B1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALDH3B1 |
|---|---|
| Synonyms | ALDH7 |
| Function | Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:23721920). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292). Short-chain fatty aldehydes are not good substrates (PubMed:17382292). Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels (PubMed:17382292). Low activity towards acetaldehyde and 3,4- dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (PubMed:17382292). |
| Cellular Location | Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm |
| Tissue Location | Highest expression in kidney and lung. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation.
REFERENCES
Marchitti,S.A., et.al., Biochem. Biophys. Res. Commun. 356 (3), 792-798 (2007)
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