癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LRRC4 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9HBW1 |
| Other Accession | Q45R42, Q99PH1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72717 Da |
| Antigen Region | 531-559 aa |
| Gene ID | 64101 |
|---|---|
| Other Names | Leucine-rich repeat-containing protein 4, Brain tumor-associated protein BAG, Nasopharyngeal carcinoma-associated gene 14 protein, Netrin-G2 ligand, NGL-2, LRRC4, BAG |
| Target/Specificity | This LRRC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-559 amino acids from the C-terminal region of human LRRC4. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LRRC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LRRC4 |
|---|---|
| Synonyms | BAG |
| Function | Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Postsynaptic cell membrane. Note=LRRC4 and DLG4 are interdependent for synaptic localization. |
| Tissue Location | Specifically expressed in brain. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The exact function of LRRC4 is unknown.
REFERENCES
Wu, M., et al. J. Cell. Physiol. 214(1):65-74(2008)
Zhang, Z., et al. BMC Mol. Biol. 9, 99 (2008) :
Wu, M., et al. J. Neurooncol. 80(2):133-142(2006)
Wu, M., et al. Mol. Biol. Cell 17(8):3534-3542(2006)
Zhang, Q.H., et al. Acta Biochim. Biophys. Sin. (Shanghai) 37(10):680-687(2005)
Zhang, Q.H., et al. Acta Biochim. Biophys. Sin. (Shanghai) 37(8):532-540(2005)
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