癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL-9 Antibody
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- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | P15248 |
| Other Accession | NP_000581, 10834980 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 15909 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | IL-9 antibody can be used for detection of IL-9 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 3578 |
|---|---|
| Other Names | Interleukin-9, IL-9, Cytokine P40, T-cell growth factor P40, IL9 |
| Target/Specificity | IL9; IL-9 antibody is human specific. IL-9 antibody is predicted to no cross-react with IL-7. |
| Reconstitution & Storage | IL-9 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | IL-9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL9 |
|---|---|
| Function | Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5. |
| Cellular Location | Secreted. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Interleukin 9 (IL-9) is a cytokine secreted by TH2 lymphocytes that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation and prevents apoptosis (1,2). It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins (3). The IL-9 gene has been identified as a candidate gene for asthma (4). Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness (5).
REFERENCES
Renauld JC, Goethals A, Houssiau F, et al. Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40. Cytokine 1990; 2:9-12.
Tete S, Saggini A, Maccauro G, et al. Interleukin-9 and mast cells. J. Biol. Homeost. Agents 2012; 26:319-26.
Knoops L and Renauld JC. IL-9 and its receptor: from signal transduction to tumorigenesis. Growth Factors 2004; 22:207-15.
Nicolaides NC, Holroyd KJ, Ewart SL, et al. Interleukin 9: a candidate gene for asthma. Proc. Natl. Acad. Sci. USA 1997; 94:13175-80.
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