癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FUCA1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FUCA1.
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P04066 |
| Other Accession | BC017338 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 1D4 |
| Calculated MW | 53689 Da |
| Gene ID | 2517 |
|---|---|
| Other Names | Tissue alpha-L-fucosidase, Alpha-L-fucosidase I, Alpha-L-fucoside fucohydrolase 1, Alpha-L-fucosidase 1, FUCA1 |
| Target/Specificity | FUCA1 (AAH17338, 23 a.a. ~ 461 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FUCA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.
REFERENCES
Spectrofluorimetric method for measuring the activity of the enzyme alpha-L-fucosidase using the ion associate of 2-chloro-4-nitro phenol-rhodamine-B. El-Shahawi MS, et al. Talanta, 2009 Nov 15. PMID 19782187. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Palmieri RT, et al. Cancer Epidemiol Biomarkers Prev, 2008 Dec. PMID 19064572. Activity of lysosomal exoglycosidases in saliva of patients with HIV infection. Kna? M, et al. Adv Med Sci, 2007. PMID 18217416. Crypticity and functional distribution of the membrane associated alpha-L-fucosidase of human sperm. Venditti JJ, et al. Mol Reprod Dev, 2007 Jun. PMID 17133604.
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