β-tubulin-III

Mouse Monoclonal antibody(Mab)

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	Q13509
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Clone Names	500D5G6
Calculated MW	50433 Da

Additional Information
Gene ID	10381
Gene Name	TUBB3
Other Names	Tubulin beta-3 chain, Tubulin beta-4 chain, Tubulin beta-III, TUBB3, TUBB4
Dilution	IHC-P~~Ready-to-use
Storage	Maintain refrigerated at 2-8°C.
Precautions	β-tubulin-III Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	TUBB3
Synonyms	TUBB4
Function	Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).
Cellular Location	Cytoplasm, cytoskeleton. Cell projection, growth cone {ECO:0000250\|UniProtKB:Q9ERD7}. Cell projection, lamellipodium {ECO:0000250\|UniProtKB:Q9ERD7}. Cell projection, filopodium {ECO:0000250\|UniProtKB:Q9ERD7}
Tissue Location	Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.