癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ITGAX/CD11c Antibody (N-term)
Mouse Monoclonal Antibody (Mab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P20702 |
| Other Accession | NP_000878.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 428CT12.2.6.4 |
| Calculated MW | 127829 Da |
| Gene ID | 3687 |
|---|---|
| Other Names | Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, CD11c, ITGAX, CD11C |
| Target/Specificity | This ITGAX/CD11c antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 246-274 amino acids from the N-terminal region of human ITGAX/CD11c. |
| Dilution | WB~~1:100~500 |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ITGAX/CD11c Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITGAX |
|---|---|
| Synonyms | CD11C |
| Function | Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Predominantly expressed in monocytes and granulocytes |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.
REFERENCES
Van Brussel, I., et al. J. Immunol. Methods 362 (1-2), 168-175 (2010) :
Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(33):14727-14732(2010)
Lindsay, R.W., et al. J. Immunol. 185(3):1513-1521(2010)
Kraus, T.S., et al. Am. J. Clin. Pathol. 134(2):271-277(2010)
Quist, S.R., et al. Acta Derm. Venereol. 90(4):429-430(2010)
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