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>   首页   >   产品   >   一抗   >   癌症   >   HKLK3 Antibody (C234)   

HKLK3 Antibody (C234)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - HKLK3 Antibody (C234) AM2088b
    HKLK3 Antibody (C234)(Cat. #AM2088b) western blot analysis in MDA-MB231 cell line lysates (35μg/lane).This demonstrates the HKLK3 antibody detected the HKLK3 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P07288
Other Accession NP_001639
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 551CT16.3.5
Calculated MW 28741 Da
Additional info
Gene ID 354
Other Names Prostate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS
Target/Specificity This HKLK3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 220-250 amino acids from human HKLK3.
Dilution WB~~1:100
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHKLK3 Antibody (C234) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLK3
Synonyms APS
Function Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Cellular Location Secreted.
Research Areas

BACKGROUND

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.

REFERENCES

Kim, S.T., et al. Prostate 70(16):1729-1738(2010)
Kuasne, H., et al. Cancer Invest. 28(9):917-924(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Sarrats, A., et al. OMICS 14(4):465-474(2010)
Gallagher, D.J., et al. Clin. Cancer Res. 16(10):2819-2832(2010)

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