癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MCHR1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q99705 |
| Other Accession | P97639, Q8JZL2, NP_005288.3 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38940 Da |
| Antigen Region | 342-353 aa |
| Gene ID | 2847 |
|---|---|
| Other Names | Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, MCH1R, MCHR, SLC-1, Somatostatin receptor-like protein, MCHR1, GPR24, SLC1 |
| Target/Specificity | This MCHR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-422 amino acids from the C-terminal region of human MCHR1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MCHR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MCHR1 (HGNC:4479) |
|---|---|
| Synonyms | GPR24, SLC1 |
| Function | Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
REFERENCES
Miyamoto-Matsubara, M., et al. Ann. N. Y. Acad. Sci. 1200, 112-119 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009) :
Gavalas, N.G., et al. Exp. Dermatol. 18(5):454-463(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
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