癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ENTPD3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | O75355 |
| Other Accession | NP_001239.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59105 Da |
| Antigen Region | 496-527 aa |
| Gene ID | 956 |
|---|---|
| Other Names | Ectonucleoside triphosphate diphosphohydrolase 3, NTPDase 3, CD39 antigen-like 3, Ecto-ATP diphosphohydrolase 3, Ecto-ATPDase 3, Ecto-ATPase 3, Ecto-apyrase 3, HB6, ENTPD3, CD39L3 |
| Target/Specificity | This ENTPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-527 amino acids from the C-terminal region of human ENTPD3. |
| Dilution | WB~~1:2000 IHC-P~~N/A FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ENTPD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ENTPD3 |
|---|---|
| Synonyms | CD39L3 {ECO:0000303|PubMed:9676430} |
| Function | Has a threefold preference for the hydrolysis of ATP over ADP. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BFW6}; Multi-pass membrane protein |
| Tissue Location | Expressed in adult brain, pancreas, spleen and prostate (PubMed:9676430). Moderate or low expression is seen in most tissues (PubMed:9676430). Not expressed in liver and peripheral blood leukocytes (PubMed:9676430). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.
REFERENCES
Fausther, M., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 298 (6), L804-L818 (2010) :
Gaddie, K.J., et al. Biochemistry 48(40):9437-9447(2009)
Munkonda, M.N., et al. FEBS J. 276(2):479-496(2009)
Munkonda, M.N., et al. Biochem. Pharmacol. 74(10):1524-1534(2007)
Ivanenkov, V.V., et al. Biochemistry 44(25):8998-9012(2005)
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