癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CENTG1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q99490 |
| Other Accession | Q8CGU4, Q3UHD9, NP_001116244.1, NP_055585.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 124591 Da |
| Antigen Region | 850-877 aa |
| Gene ID | 116986 |
|---|---|
| Other Names | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, AGAP-2, Centaurin-gamma-1, Cnt-g1, GTP-binding and GTPase-activating protein 2, GGAP2, Phosphatidylinositol 3-kinase enhancer, PIKE, AGAP2, CENTG1, KIAA0167 |
| Target/Specificity | This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CENTG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGAP2 |
|---|---|
| Synonyms | CENTG1, KIAA0167 |
| Function | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
| Cellular Location | [Isoform 1]: Cytoplasm. Nucleus. |
| Tissue Location | Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
REFERENCES
Shiba, Y., et al. J. Cell. Sci. 123 (PT 14), 2381-2390 (2010) :
Zhu, Y., et al. J. Biol. Chem. 284(20):13489-13496(2009)
Cai, Y., et al. Cancer Res. 69(3):819-827(2009)
Tang, X., et al. Nat. Cell Biol. 10(6):698-706(2008)
Liu, R., et al. Proc. Natl. Acad. Sci. U.S.A. 105(21):7570-7575(2008)
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