癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GPM6B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q13491 |
| Other Accession | Q9JJK1, NP_005269 |
| Reactivity | Human |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28989 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 2824 |
|---|---|
| Other Names | Neuronal membrane glycoprotein M6-b, M6b, GPM6B, M6B |
| Target/Specificity | This GPM6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GPM6B. |
| Dilution | WB~~1:2000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPM6B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPM6B |
|---|---|
| Synonyms | M6B |
| Function | May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Colocalizes with SERT at the plasma membrane. |
| Tissue Location | Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions, such as membrane trafficking and cell-to-cell communication.
REFERENCES
Fjorback, A.W., et al. J. Mol. Neurosci. 37(3):191-200(2009)
Sebastiani, P., et al. Am. J. Hematol. 83(3):189-195(2008)
Combes, P., et al. Neurogenetics 7(1):31-37(2006)
Henneke, M., et al. Am. J. Med. Genet. A 128A (2), 156-158 (2004) :
Werner, H., et al. Mol. Cell. Neurosci. 18(6):593-605(2001)
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