癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Kif5C-2 Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O60282 |
| Other Accession | P28738, NP_004513.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 109495 Da |
| Gene ID | 3800 |
|---|---|
| Other Names | Kinesin heavy chain isoform 5C, Kinesin heavy chain neuron-specific 2, KIF5C, KIAA0531, NKHC2 |
| Target/Specificity | This KIF5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from human KIF5C. |
| Dilution | WB~~1:2000 IHC-P~~N/A E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Kif5C-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KIF5C |
|---|---|
| Synonyms | KIAA0531, NKHC2 |
| Function | Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, dendrite. Note=Abundant in distal regions of dendrites. |
| Tissue Location | Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Wang, X., et al. Cell 136(1):163-174(2009)
Schafer, B., et al. Cell. Mol. Life Sci. 66(2):339-349(2009)
Schafer, B., et al. Biochem. Biophys. Res. Commun. 375(2):179-183(2008)
Cho, K.I., et al. Traffic 8(12):1722-1735(2007)
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