癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OCLN Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q16625 |
| Other Accession | Q61146, NP_002529.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59144 Da |
| Antigen Region | 446-474 aa |
| Gene ID | 100506658 |
|---|---|
| Other Names | Occludin, OCLN |
| Target/Specificity | This OCLN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 446-474 amino acids from the C-terminal region of human OCLN. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OCLN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OCLN |
|---|---|
| Function | May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, tight junction |
| Tissue Location | Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described. [provided by RefSeq].
REFERENCES
Liu, S., et al. Virology 407(1):160-170(2010)
Michta, M.L., et al. J. Virol. 84(22):11696-11708(2010)
O'Driscoll, M.C., et al. Am. J. Hum. Genet. 87(3):354-364(2010)
Van Itallie, C.M., et al. J. Cell. Sci. 123 (PT 16), 2844-2852 (2010) :
Raikwar, N.S., et al. Am. J. Physiol. Renal Physiol. 299 (2), F436-F444 (2010) :
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