癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD201 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q9UNN8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26671 Da |
| Antigen Region | 104-132 aa |
| Gene ID | 10544 |
|---|---|
| Other Names | Endothelial protein C receptor, Activated protein C receptor, APC receptor, Endothelial cell protein C receptor, CD201, PROCR, EPCR |
| Target/Specificity | This CD201 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-132 amino acids from the Central region of human CD201. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD201 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PROCR |
|---|---|
| Synonyms | EPCR |
| Function | Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PROCR (CD201) is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in its gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
REFERENCES
Menschikowski,M., Exp. Cell Res. 315 (15), 2673-2682 (2009)
Nayak,R.C., Blood 114 (9), 1974-1986 (2009)
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