FAS (C-terminus) Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB |
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Primary Accession | P25445 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 37732 Da |
Gene ID | 355 |
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Other Names | ALPS 1A;ALPS1A;APO 1;Apo 1 antigen;APO 1 cell surface antigen;Apo-1 antigen;APO1;Apo1 antigen;APO1 cell surface antigen;Apoptosis antigen 1;Apoptosis mediating surface antigen FAS;Apoptosis-mediating surface antigen FAS;APT 1;APT1;CD 95;CD 95 antigen; CD95;CD95 antigen;Delta Fas;Delta Fas/APO 1/CD95;Delta Fas/APO1/CD95;Fas (TNF receptor superfamily, member 6);FAS 1;FAS 827dupA;Fas AMA;FAS;FAS Antigen;Fas cell surface death receptor;FAS1;FASLG receptor;FASTM;sFAS;Surface antigen APO1;TNF receptor superfamily, member 6;TNFRSF 6;TNFRSF6;TNR6_HUMAN;Tumor necrosis factor receptor superfamily member 6. |
Dilution | WB~~1:1000 |
Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide, 50%,glycerol |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | FAS |
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Synonyms | APT1, FAS1, TNFRSF6 |
Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft [Isoform 3]: Secreted. [Isoform 5]: Secreted. |
Tissue Location | Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
REFERENCES
Itoh N.,et al.Cell 66:233-243(1991).
Oehm A.,et al.J. Biol. Chem. 267:10709-10715(1992).
Liu C.,et al.Biochem. J. 310:957-963(1995).
Cascino I.,et al.J. Immunol. 154:2706-2713(1995).
Cascino I.,et al.J. Immunol. 156:13-17(1996).

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