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CHD4 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • 1 - CHD4 Antibody AP52781
    Western blot detection of CHD4 in K562,HelaNE,HL-60,MOLT-4,Jurkat and 293 cell lysates using CHD4 mouse mAb (1:1000 diluted).Predicted band size:260KDa.Observed band size:260KDa.
  • 5 - CHD4 Antibody AP52781
    Immunoprecipitation analysis of K562 cell lysates using CHD4 mouse mAb.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP
Primary Accession Q14839
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Calculated MW 218005 Da
Additional Information
Gene ID 1108
Other Names ATP dependent helicase CHD4;ATP-dependent helicase CHD4;CHD 4;CHD-4;CHD4;CHD4_HUMAN; Chromodomain helicase DNA binding protein 4;Chromodomain-helicase-DNA-binding protein 4;DKFZp686E06161;Mi 2 autoantigen 218 kDa protein;Mi 2b;Mi-2 autoantigen 218 kDa protein;Mi2 beta;Mi2-beta.
Dilution WB~~1:1000
IP~~1:500
Format Purified mouse monoclonal in PBS(pH 7.4)containing with 0.09% (W/V) sodium azide,50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CHD4
Function ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity).
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase (By similarity). Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687 (PubMed:27732854, PubMed:28977666). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666}
Tissue Location Widely expressed..
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

REFERENCES

Seelig H.P.,et al.Arthritis Rheum. 38:1389-1399(1995).
Scherer S.E.,et al.Nature 440:346-351(2006).
Tong J.K.,et al.Nature 395:917-921(1998).
Schmidt D.R.,et al.Biochemistry 38:14711-14717(1999).
Kim J.,et al.Immunity 10:345-355(1999).

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