癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TAF7 Antibody (C-term)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q15545 |
| Other Accession | Q9R1C0, Q4R5A5, Q6R1L1, Q2HJG8, NP_005633.2 |
| Reactivity | Human |
| Predicted | Mouse, Hamster, Monkey, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=40;M=39 KDa |
| Isotype | Rabbit Ig |
| Antigen Source | HUMAN |
| Gene ID | 6879 |
|---|---|
| Antigen Region | 308-337 |
| Other Names | TAF7; TAF2F; TAFII55; Transcription initiation factor TFIID subunit 7; RNA polymerase II TBP-associated factor subunit F; Transcription initiation factor TFIID 55 kDa subunit |
| Dilution | WB~~1:1000 |
| Target/Specificity | This TAF7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human TAF7. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TAF7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TAF7 |
|---|---|
| Synonyms | TAF2F, TAFII55 |
| Function | Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9R1C0}. |
| Tissue Location | Ubiquitous. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II.
REFERENCES
Gegonne, A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(14):5367-5372(2008)
Hartman, W.R., et al. Arch. Biochem. Biophys. 459(2):223-232(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Couture, J.F., et al. Nat. Struct. Mol. Biol. 13(2):140-146(2006)
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