癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
COPS2 Antibody (N-term)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IF, IHC-P, WB |
|---|---|
| Primary Accession | P61201 |
| Other Accession | Q6IR75, P61203, P61202, Q6IQT4, NP_004227.1 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Zebrafish, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=52;M=52;Rat=52,47 KDa |
| Isotype | Rabbit Ig |
| Antigen Source | HUMAN |
| Gene ID | 9318 |
|---|---|
| Antigen Region | 1-30 |
| Other Names | COPS2; CSN2; TRIP15; COP9 signalosome complex subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15 |
| Dilution | WB~~1:1000 IHC-P~~1:25 IF~~1:25 |
| Target/Specificity | This COPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human COPS2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | COPS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | COPS2 |
|---|---|
| Synonyms | CSN2, TRIP15 |
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. |
| Cellular Location | Cytoplasm. Nucleus |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
REFERENCES
Kob, R., et al. Cell Cycle 8(13):2041-2049(2009)
Leal, J.F., et al. Oncogene 27(14):1961-1970(2008)
Fegers, I., et al. J. Proteome Res. 6(11):4182-4188(2007)
Tenbaum, S.P., et al. Biochim. Biophys. Acta 1773(9):1447-1454(2007)
Papaioannou, M., et al. Nucl Recept Signal 5, E008 (2007) :
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