癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Calcineurin Alpha Antibody (Monoclonal, CN-A1)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P63100 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Mouse IgG monoclonal antibody for Calcineurin alpha, protein phosphatase 3, regulatory subunit B, alpha (PPP3R1) detection. Tested with WB, IHC-P in Human;bovine;rat. No cross reactivity with other proteins. |
| Gene ID | 29748 |
|---|---|
| Other Names | Calcineurin subunit B type 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1, Ppp3r1, Cna2, Cnb |
| Calculated MW | 19300 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, bovine, rat, By Heat Western blot, 0.25-0.5 µg/ml, Human, bovine, rat |
| Subcellular Localization | Cytoplasm, cytosol . Cell membrane ; Lipid-anchor . Cell membrane, sarcolemma. Translocates from the cytosol to the sarcolemma in a CIB1- dependent manner during cardiomyocytes hypertrophy. . |
| Tissue Specificity | Isoform 2 is testis specific. . |
| Source | Eukaryota |
| Protein Name | Calcineurin subunit B type 1 |
| Contents | Each vial contains 50% glycerol, 1.2% Sodium acetate, 1% BSA, 0.02% NaN3. |
| Clone Names | CN-A1 |
| Immunogen | Bovine brain calcineurin. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the calcineurin regulatory subunit family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ppp3r1 |
|---|---|
| Synonyms | Cna2, Cnb |
| Function | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000250|UniProtKB:Q63810}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q63810}. Cell membrane {ECO:0000250|UniProtKB:P63098}; Lipid-anchor {ECO:0000250|UniProtKB:P63098}. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocyte hypertrophy. {ECO:0000250|UniProtKB:Q63810} |
| Tissue Location | Isoform 2 is testis specific. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Calcineurin, the Ca(2+)/calmodulin-regulated protein phosphatase, first detected in skeletal muscle and brain, has been found in all cells from yeast to mammals. Calcineurin A alpha(PPP3CA),is located on human chromosomes 4, Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase(calcineurin) catalytic subunit. Calcineurin regulates bone formation by the osteoblast.
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