癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Catenin Gamma (Plakoglobin) Antibody (Monoclonal, 15F11)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-F, ICC |
|---|---|
| Primary Accession | Q6P0K8 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Catenin gamma (Plakoglobin), junction plakoglobin ( JUP) detection. Tested with WB, IHC-F, ICC in Human;bovine. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 81679 |
|---|---|
| Other Names | Junction plakoglobin, Jup |
| Calculated MW | 81801 Da |
| Application Details | Immunocytochemistry , 1 µg/ml, Human, bovine, - Immunohistochemistry(Frozen Section), 4 µg/ml, Human, bovine, - Western blot, 2 µg/ml, Human, bovine |
| Subcellular Localization | Cell junction, adherens junction . Cell junction, desmosome . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cytoplasmic in a soluble and membrane-associated form. . |
| Source | Eukaryota |
| Protein Name | Junction plakoglobin |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | 15F11 |
| Immunogen | Recombinant chicken plakoglobin. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the beta-catenin family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Jup {ECO:0000312|RGD:620412} |
|---|---|
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity). |
| Cellular Location | Cell junction, adherens junction {ECO:0000250|UniProtKB:P14923}. Cell junction, desmosome. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P14923}. Cell membrane {ECO:0000250|UniProtKB:P14923}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14923}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7} Cell projection, axon {ECO:0000250|UniProtKB:Q02257}. Note=Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (By similarity). {ECO:0000250|UniProtKB:P14923} |
| Tissue Location | Expressed in the heart (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Junction Plakoglobin(JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
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