癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Elastin Antibody (Monoclonal, BA-4)
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- 背景知识
Application 
| IHC-P |
|---|---|
| Primary Accession | P15502 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Elastin, elastin (ELN ) detection. Tested with IHC-P in Human; bovine. No cross reactivity with otherproteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 2006 |
|---|---|
| Other Names | Elastin, Tropoelastin, ELN |
| Calculated MW | 68398 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.25-0.5 µg/ml, Bovine, human, By Heat |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix . Extracellular matrix of elastic fibers. . |
| Tissue Specificity | Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin. . |
| Source | Eukaryota |
| Protein Name | Elastin |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | BA-4 |
| Immunogen | Bovine alpha-elastin. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the elastin family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ELN |
|---|---|
| Function | Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers. |
| Tissue Location | Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Elastin is a major structural protein of tissues such as aorta, which must expand rapidly and recover completely. Elastin chains are cross-linked together into an extensible 3D network. It is a molecular determinant of late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in elastin are a cause of autosomal dominant cutis laxa.
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