癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GFAP Antibody (Monoclonal, G-A-5)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F |
|---|---|
| Primary Accession | P47819 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Rat, Pig |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for GFAP, glial fibrillary acidic protein (GFAP) detection. Tested with WB, IHC-P, IHC-F in Human;pig;rat. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 24387 |
|---|---|
| Other Names | Glial fibrillary acidic protein, GFAP, Gfap |
| Calculated MW | 49957 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.4-1 µg/ml, Human, pig, rat, By Heat Immunohistochemistry(Frozen Section), 0.5-1 µg/ml, Human, pig, rat, - Western blot, 0.5-1 µg/ml, Human, pig, rat |
| Subcellular Localization | Cytoplasm . Associated with intermediate filaments. . |
| Tissue Specificity | Expressed in the cortex and hippocampus. Expression decreases following acute and chronic corticosterone treatment. . |
| Source | Eukaryota |
| Protein Name | Glial fibrillary acidic protein |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | G-A-5 |
| Immunogen | GFAP from pig spinal cord. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the intermediate filament family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Gfap |
|---|---|
| Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P14136}. Note=Associated with intermediate filaments {ECO:0000250|UniProtKB:P14136} |
| Tissue Location | Expressed in the cortex and hippocampus. Expression decreases following acute and chronic corticosterone treatment |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Glial fibrillary acidic protein(GFAP) is an intermediate filament protein of 52Kda. GFAP gene is mapped to human 17q21. GFAP is a useful marker of astroglia in the brain. Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease.
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