癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-MAP1 Antibody (Monoclonal, HM-1)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F |
|---|---|
| Primary Accession | P34926 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Mouse, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for MAP1, microtubule-associated protein 1A (MAP1A) detection. Tested with WB, IHC-P, IHC-F in Mouse;rat. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 25152 |
|---|---|
| Other Names | Microtubule-associated protein 1A, MAP-1A, MAP1A heavy chain, MAP1 light chain LC2, Map1a, Mtap1a |
| Calculated MW | 299531 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 1-2 µg/ml, Mouse, rat, By Heat Immunohistochemistry(Frozen Section), 1-2 µg/ml, Mouse, rat, - Western blot, 0.5-2 µg/ml, Mouse, rat |
| Subcellular Localization | Cytoplasm, cytoskeleton . |
| Tissue Specificity | Brain, heart and muscle. |
| Source | Eukaryota |
| Protein Name | Microtubule-associated protein 1A |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | HM-1 |
| Immunogen | Rat brain microtubule-associated proteins(MAPs). |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Map1a |
|---|---|
| Synonyms | Mtap1a |
| Function | Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. |
| Cellular Location | Cytoplasm, cytoskeleton. |
| Tissue Location | Brain, heart and muscle. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Microtubules are the ubiquitous cytoskeletal structural components that are involved in intracellular transport. They are composed of tubulin and microtubule-associated proteins(MAPs). MAP1 is one of the major neuronal MAPs as well as being the largest(350KD). MAPs include MAP1A, MAP1B, and MAP2. MAP1a is a single-copy gene spanning 10.5 kb. MAP1a coding sequence is contained in five exons. MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain.
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