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Anti-Myosin(Skeletal, Slow) Antibody (Monoclonal, NOQ7.5.4D)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P02564 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Myosin (Skeletal, Slow), myosin, heavy chain 7, cardiac muscle, beta (MYH7) detection. Tested with WB, IHC-P in Human;mouse;rabbit;rat. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 29557 |
|---|---|
| Other Names | Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta, Myh7 |
| Calculated MW | 223083 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 1-2 µg/ml, Human, mouse, rabbit, rat, By Heat Western blot, 0.5-2 µg/ml, Human, mouse, rabbit, rat |
| Subcellular Localization | Cytoplasm, myofibril. Thick filaments of the myofibrils. |
| Tissue Specificity | MYH7: Both wild type and variant Gln-403 aredetected in skeletal muscle (at protein level). |
| Source | Eukaryota |
| Protein Name | Myosin-7 |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | NOQ7.5.4D |
| Immunogen | Human skeletal muscle myosin purified from myofibrils. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Myh7 |
|---|---|
| Function | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. |
| Cellular Location | Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere. Note=Thick filaments of the myofibrils |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Myosin is composed of 2 heavy chains of about 200,000 daltons each and 4 light chains of about 20,000 daltons each. Skeletal Myosin(slow),, also known as light chain 3(MYL3), mapped to 3p. Fodor et al.(1989) found that the MYL3 gene has 7 exons, the last of which is completely untranslated 3-prime sequence.
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