癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-p16INK4a/CDKN2 Antibody (Monoclonal, DCS-50)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-F, ICC |
|---|---|
| Primary Accession | Q9R0Z3 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for p16INK4a/CDKN2, cyclin-dependent kinase inhibitor 2A (CDKN2A) detection. Tested with WB, IHC-F, ICC in Human. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 25163 |
|---|---|
| Other Names | Cyclin-dependent kinase inhibitor 2A {ECO:0000312|RGD:2323}, Cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4a, p16, p16-INK4, Cdkn2a {ECO:0000312|EMBL:AAL76338.1, ECO:0000312|RGD:2323} |
| Calculated MW | 17366 Da |
| Application Details | Immunocytochemistry , 1 µg/ml, Human, - Immunohistochemistry(Frozen Section), 1-2 µg/ml, Human, - Western blot, 0.5-1 µg/ml, Human |
| Subcellular Localization | Cytoplasm . Nucleus . |
| Tissue Specificity | Expressed in spleen, liver and lung. Not detected in kidney, colon, stomach or brain. . |
| Source | Eukaryota |
| Protein Name | Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | DCS-50 |
| Immunogen | Recombinant human p16 protein. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Cdkn2a {ECO:0000312|EMBL:AAL76338.1, ECO:0000312|RGD:2323} |
|---|---|
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed in spleen, liver and lung. Not detected in kidney, colon, stomach or brain. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
p16(INK4A), also known as cyclin-dependent kinase inhibitor 2A(CDKN2A), or multiple tumor suppressor 1(MTS1). The p16 gene(CDKN2A) was mapped to 9p21. The p16 gene encodes a negative regulator of the cell cycle. CDKN2 plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. Germ-line mutations in the CDKN2A tumor-suppressor gene have been linked to the development of melanoma in some families with inherited melanoma.
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