癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-p19INK4d Antibody (Monoclonal, DCS-100)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | Q60773 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for p19INK4d, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (CDKN2D) detection. Tested with WB, IHC-P, ICC in Human. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 12581 |
|---|---|
| Other Names | Cyclin-dependent kinase 4 inhibitor D, p19-INK4d, Cdkn2d |
| Calculated MW | 17809 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 1-2 µg/ml, Human, By Heat Immunocytochemistry , 1 µg/ml, Human, - Western blot, 0.5-1 µg/ml, Human |
| Subcellular Localization | Nucleus . Cytoplasm . |
| Source | Eukaryota |
| Protein Name | Cyclin-dependent kinase 4 inhibitor D |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | DCS-100 |
| Immunogen | Recombinant human p19INK4d. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Cdkn2d |
|---|---|
| Function | Interacts strongly with CDK4 and CDK6 and inhibits them. |
| Cellular Location | Nucleus. Cytoplasm. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclin-dependent kinases. P19(INK4d) also kowns as cyclin-dependent kinase inhibitor 2D, is one of the novel members of the mouse INK4 gene family. Okuda et al.(1995) described the cloning of the human INK4d gene(CDKN2D). The predicted 166-amino acid protein is 86% identical to the mouse protein and about 45% identical to other human INK4 family members.
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