癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-PCK Antibody (Monoclonal, C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F |
|---|---|
| Primary Accession | P04264 |
| Host | Mouse |
| Isotype | Mouse IgG2a/ IgG1 |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for PCK detection. Tested with WB, IHC-P, IHC-F in Human;rat. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 3848 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Hair alpha protein, Keratin-1, K1, Type-II keratin Kb1, KRT1, KRTA |
| Calculated MW | 66039 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.1-0.5 µg/ml, Human, rat, By Heat Immunohistochemistry(Frozen Section), 0.1-0.5 µg/ml, Human, rat, - Western blot, 1-2 µg/ml, Human, rat |
| Subcellular Localization | Cell membrane . Located on plasma membrane of neuroblastoma NMB7 cells. |
| Tissue Specificity | The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis. |
| Source | Eukaryota |
| Protein Name | Keratin, type II cytoskeletal 1 |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | C-11+PCK-26+CY-90+KS-1A3+M20+A53-B/A2 |
| Immunogen | mixture of several monoclonal cytokeratin clones. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the intermediate filament family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT1 (HGNC:6412) |
|---|---|
| Synonyms | KRTA |
| Function | Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers with a type I keratin, assembling into keratin intermediate filament networks that provide mechanical strength and structural stability to differentiating epidermal cells (PubMed:1381288). May regulate the activity of kinases such as PKC and SRC by interacting with integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1) (PubMed:17956333, PubMed:21544310). In complex with C1QBP, acts as a high-affinity receptor for kininogen-1 (HMWK) (PubMed:21544310). |
| Cellular Location | Cell membrane. Cytoplasm |
| Tissue Location | The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Monoclonal anti cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal Anti Pan Cytokeratin(mixture) is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues.
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