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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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Anti-Aquaporin 5 Antibody
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- 背景知识
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9WTY4 |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Aquaporin-5(AQP5) detection. Tested with WB, IHC-P in Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 11830 |
|---|---|
| Other Names | Aquaporin-5, AQP-5, Aqp5 |
| Calculated MW | 28274 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Rat, Mouse, By Heat Western blot, 0.1-0.5 µg/ml, Rat, Mouse |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Source | Eukaryota |
| Protein Name | Aquaporin-5(AQP-5) |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse AQP5(246-265aa EEDWEDHREERKKTIELTAH), identical to the related rat sequence. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Aqp5 {ECO:0000312|MGI:MGI:106215} |
|---|---|
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (By similarity). Plays an important role in fluid secretion in salivary glands (PubMed:10400615, PubMed:16571723, PubMed:18027168). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (PubMed:10619865, PubMed:12042359, PubMed:18027168). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Cell membrane {ECO:0000250|UniProtKB:P55064}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Cytoplasmic vesicle membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55064}. Note=Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane. {ECO:0000250|UniProtKB:P55064} |
| Tissue Location | Detected at the luminal membrane of secretory epithelial cells in hindpaw sweat glands (PubMed:12042359, PubMed:23473857). Detected in acinar cells in salivary glands, in duct cells in lacrimal glands and in lung (at protein level) (PubMed:10337625, PubMed:10400615, PubMed:10619865, PubMed:16571723, PubMed:18027168). Detected in lung, parotid, submandibular, sublingual, and lacrimal gland tissues (PubMed:10337625) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Aquaporin 5, also known as AQP5, is a water channel protein. The aquaporins(AQPs) are a family of more than 10 homologous water transporting proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are expressed in the eye: AQP0(MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary epithelium and retinal Müller cells, and AQP5 in corneal and lacrimal gland epithelia. Among the seven human aquaporins cloned to date(AQPs 0-6), genes encoding the four most closely related aquaporins(AQP0, AQP2, AQP5, and AQP6) have been mapped to chromosome band 12q13, suggesting an aquaporin family gene cluster at this locus. Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions.
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