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Anti-CaMKK Antibody
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- 背景知识
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q8VBY2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1(CAMKK1) detection. Tested with WB, IHC-P in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 55984 |
|---|---|
| Other Names | Calcium/calmodulin-dependent protein kinase kinase 1, CaM-KK 1, CaM-kinase kinase 1, CaMKK 1, 2.7.11.17, CaM-kinase IV kinase, Calcium/calmodulin-dependent protein kinase kinase alpha, CaM-KK alpha, CaM-kinase kinase alpha, CaMKK alpha, Camkk1, Camkk |
| Calculated MW | 55838 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Rat, Mouse, By Heat Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat |
| Subcellular Localization | Cytoplasm . Nucleus . |
| Tissue Specificity | Widely expressed. Differentially expressed in various brain regions. . |
| Source | Eukaryota |
| Protein Name | Calcium/calmodulin-dependent protein kinase kinase 1(CaM-KK 1/CaM-kinase kinase 1/CaMKK 1) |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK(10-31aa QDPRAELVDRVAAINVAHLEEA), different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Camkk1 |
|---|---|
| Synonyms | Camkk |
| Function | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Widely expressed. Differentially expressed in various brain regions. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The CAMKK1 gene is mapped to chromosome 17. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.Camkk1binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. Camkk1 catalyzed a 10-fold increase in the total activity of Camk1 and had no effect on Camk2. Cotransfection of COS-7 cells with Camkk1 and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that Camkk1 enhances Camk4-mediated transcriptional regulation.
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