癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-CD89 Antibody
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Application 
| WB |
|---|---|
| Primary Accession | P24071 |
| Host | Rabbit |
| Reactivity | Human |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Immunoglobulin alpha Fc receptor(FCAR) detection. Tested with WB in Human. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 2204 |
|---|---|
| Other Names | Immunoglobulin alpha Fc receptor, IgA Fc receptor, CD89, FCAR, CD89 |
| Calculated MW | 32265 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human |
| Subcellular Localization | Isoform A.1: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. . |
| Source | Eukaryota |
| Protein Name | Immunoglobulin alpha Fc receptor(IgA Fc receptor) |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle of human CD89(84-101aa EFVIDHMDANKAGRYQCQ). |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FCAR |
|---|---|
| Synonyms | CD89 |
| Function | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. |
| Cellular Location | [Isoform A.1]: Cell membrane; Single-pass type I membrane protein [Isoform A.3]: Cell membrane; Single-pass type I membrane protein [Isoform B-delta-S2]: Secreted. |
| Tissue Location | Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FCAR, Receptor for Fc fragment of IGA, is also known as CD89. Human Fc-alpha receptor(FCAR) is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types. FCAR is mapped to 19q13.4. Human COS cells transfected with FCAR cDNA bind to IgA, but not IgG.
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