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Anti-HYAL2 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q12891 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Hyaluronidase-2(HYAL2) detection. Tested with WB in Human;Mouse;Rat. . |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 8692 |
|---|---|
| Other Names | Hyaluronidase-2, Hyal-2, 3.2.1.35, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2 |
| Calculated MW | 53860 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse |
| Subcellular Localization | Cell membrane ; Lipid-anchor, GPI-anchor . |
| Tissue Specificity | Widely expressed. No expression detected in adult brain. . |
| Source | Eukaryota |
| Protein Name | Hyaluronidase-2(Hyal-2) |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human HYAL2(142-157aa VRNWQDKDVYRRLSRQ), different from the related mouse and rat sequences by three amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the glycosyl hydrolase 56 family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HYAL2 |
|---|---|
| Synonyms | LUCA2 |
| Function | Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases (PubMed:9712871). Essential for the breakdown of extracellular matrix hyaluronan (PubMed:28081210). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
| Tissue Location | Widely expressed (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HYAL2(hyaluronoglucosaminidase 2) also known as hyaluronidase 2, LuCa-2, is an enzyme that in humans is encoded by the HYAL2 gene. HYAL2 cDNAs encode a preprotein with an N-terminal signal peptide. Northern blot analysis indicated that HYAL2 was expressed in all human tissues tested except adult brain, and Western blot analysis detected Hyal2protein in all mouse tissues examined except adult brain. The HYAL2 gene is mapped on 3p21.31. HYAL2 is a glycosylphosphatidylinositol(GPI)-anchored protein on the cell surface and serves as a receptor for entry into the cell of the jaagsiekte sheep retrovirus(JSRV). The findings of Rai et al.(2001) that HYAL2 is a GPI-anchored protein on the cell surface showed that GFP would likely be cleaved from HYAL2 during GPI addition, leaving HYAL2 on the cell surface and resulting in GFP transit to the lysosome for degradation.
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