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Anti-TXNRD2 Antibody
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- 实验流程
- 背景知识
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9NNW7 |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Thioredoxin reductase 2, mitochondrial(TXNRD2) detection. Tested with WB, IHC-P in Human;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 10587 |
|---|---|
| Other Names | Thioredoxin reductase 2, mitochondrial, 1.8.1.9, Selenoprotein Z, SelZ, TR-beta, Thioredoxin reductase TR3, TXNRD2, KIAA1652, TRXR2 |
| Calculated MW | 56507 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, By Heat Western blot, 0.1-0.5 µg/ml, Human, Rat |
| Subcellular Localization | Mitochondrion . |
| Tissue Specificity | Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. . |
| Source | Eukaryota |
| Protein Name | Thioredoxin reductase 2, mitochondrial |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human TXNRD2(418-434aa RHGQEHVEVYHAHYKPL), different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TXNRD2 (HGNC:18155) |
|---|---|
| Synonyms | KIAA1652, TRXR2 |
| Function | Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox- regulated cell signaling. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TXNRD2(Thioredoxin reductase 2), also known as TRXR2, TR3, SELZ, or TR-BETA, Thioredoxin reductases, are selenocysteine(sec)-containing flavoenzymes that maintain thioredoxins, small proteins that catalyze redox reactions, in the reduced state using the reducing power of NADPH. By STS analysis and genomic sequence analysis, respectively, Miranda-Vizuete et al.(1999) and Sun et al.(1999) mapped the TXNRD2 gene to chromosome 22q11.2. Miranda-Vizuete et al.(1999) mapped the mouse gene to chromosome 16. Gasdaska et al.(1999) showed that TXNRD2 was a thioredoxin reductase that could directly reduce proteins such as insulin.
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