癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-TRAF1 Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q13077 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for TNF receptor-associated factor 1(TRAF1) detection. Tested with WB in Human;Mouse. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 7185 |
|---|---|
| Other Names | TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6 |
| Calculated MW | 46164 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human, Mouse |
| Source | Eukaryota |
| Protein Name | TNF receptor-associated factor 1 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human TRAF1(220-235aa HQSQLDRERILSLEQR), different from the related mouse sequence by one amino acid. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Contains 1 MATH domain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TRAF1 |
|---|---|
| Synonyms | EBI6 |
| Function | Adapter molecule that is involved in multiple signaling pathways including the NF-kappa-B and MAPK pathways and thus influences inflammatory and apoptotic responses. Plays a critical role in regulating T-cell activation both through restricting the costimulation-independent activation of NIK in activated T-cells and by promoting the TNFRSF9-induced classical NF-kappa-B pathway (By similarity). Forms a heterotrimer with TRAF2 as part of an E3 ubiquitin-protein ligase complex that mediates ubiquitination of target proteins such as MAP3K14 and gasdermin D/GSDMD (PubMed:40097387). This complex also recruits the antiapoptotic E3 ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (PubMed:19287455). Acts downstream of MAVS within the RIG-I/MAVS antiviral pathway to enhance type I interferon signaling (PubMed:38995016). Regulates osteoclastogenesis by preventing ubiquitination and degradation of MLST8, thereby promoting PI3K-AKT signaling and enhancing oxidative phosphorylation in osteoclasts (By similarity). |
| Cellular Location | Cytoplasm. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TRAF1(TNF Receptor-Associated Factor 1), also called EBI6, is a protein that in humans is encoded by the TRAF1 gene. The protein encoded by this gene is a member of the TNF receptor(TNFR) associated factor(TRAF) protein family. Siemienski et al.(1997) used fluorescence in situ hybridization to map the TRAF1 gene to 9q33-q34. Mosialos et al.(1995) found that LMP1, the EBV-transforming protein, specifically associates with LAP1(TRAF3) or EBI6 in B lymphoblasts. LMP1 expression redirects LAP1 and EBI6 from scattered cytoplasmic structures to LMP1 plasma membrane patches. Both LAP1 and EBI6 associated with the cytoplasmic domain of p80/TNFR2 in vivo.
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