癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Periostin/OSF2 Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q62009 |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Periostin(POSTN) detection. Tested with WB in Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 50706 |
|---|---|
| Other Names | Periostin, PN, Osteoblast-specific factor 2, OSF-2, Postn, Osf2 |
| Calculated MW | 93144 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml, Mouse, Rat |
| Subcellular Localization | Golgi apparatus. Secreted, extracellular space, extracellular matrix. Colocalizes with BMP1 in the Golgi. |
| Tissue Specificity | Preferentially expressed in periosteum and periodontal ligament. Also expressed in the developing and adult heart. . |
| Source | Eukaryota |
| Protein Name | Periostin |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of mouse Periostin(24-41aa NSYYDKVLAHSRIRGRDQ), identical to the related rat sequence, and different from the related human sequence by three amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Contains 1 EMI domain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Postn |
|---|---|
| Synonyms | Osf2 |
| Function | Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:10404027). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (PubMed:20181949). |
| Cellular Location | Golgi apparatus. Secreted Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi (PubMed:20181949). |
| Tissue Location | Preferentially expressed in periosteum and periodontal ligament (PubMed:10404027). Also expressed in the developing and adult heart (PubMed:11335131) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
POSTN(Periostin), also known as PN or OSF2, is a protein that in humans is encoded by the POSTN gene. The International Radiation Hybrid Mapping Consortium mapped the POSTN gene to chromosome 13. Gillan et al.(2002) found that purified recombinant PN supported adhesion of ovarian epithelial cells. Shao et al.(2004) found that periostin was overexpressed by the majority of human primary breast cancers examined. Transfected tumor cell lines overexpressing periostin showed accelerated growth and angiogenesis as xenografts in immunocompromised animals. Kuhn et al.(2007) showed that extracellular periostin induced reentry of differentiated mammalian cardiomyocytes into the cell cycle.
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