癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Anti-RGS3 Antibody
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9DC04 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Regulator of G-protein signaling 3(Rgs3) detection. Tested with WB, IHC-P in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 50780 |
|---|---|
| Other Names | Regulator of G-protein signaling 3, RGS3, C2PA, Rgs3 |
| Calculated MW | 106219 Da |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse |
| Subcellular Localization | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. The long isoforms are cytoplasmic. |
| Tissue Specificity | Detected in embryos from E8.5-16.5 in cortical ventricular zone, dorsal root ganglia and cerebellar primordia. Isoform 3 is detected in testis and in spermatocytes from newborn mice. Levels increase and reach a maximum after 21 days; after this they decrease again. Long isoforms are widely expressed. . |
| Source | Eukaryota |
| Protein Name | Regulator of G-protein signaling 3 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse RGS3(909-925aa DSYTREHTKENLQSITR), identical to the related rat sequence, and different from the related human sequence by two amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Contains 1 PDZ (DHR) domain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Rgs3 |
|---|---|
| Function | Down-regulates signaling from heterotrimeric G proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G protein- mediated release of inositol phosphates and activation of MAP kinases. |
| Cellular Location | Cytoplasm. Cell membrane {ECO:0000250|UniProtKB:P49796}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49796}; Cytoplasmic side {ECO:0000250|UniProtKB:P49796}. Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear {ECO:0000250|UniProtKB:P49796} [Isoform 3]: Nucleus |
| Tissue Location | Detected in embryos from E8.5-16.5 in cortical ventricular zone, dorsal root ganglia and cerebellar primordia. Isoform 3 is detected in testis and in spermatocytes from newborn mice. Levels increase and reach a maximum after 21 days; after this they decrease again. Long isoforms are widely expressed |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
RGS3(Regulator of G Protein Signaling 3), is a protein that in humans is encoded by the RGS3 gene. Chatterjee et al.(1997) studied RGS3, the largest member of the RGS family then identified. Mouse Pdz-Rgs3 can mediate signaling from the ephrin-B cytoplasmic tail. By radiation hybrid mapping, Chatterjee et al.(1997) assigned the RGS3 gene to chromosome 9q31-q33. Lu et al.(2001) showed that Sdf1, a chemokine with a G protein-coupled receptor, and Bdnf are chemoattractants for cerebellar granule cells, and that Sdf1 chemoattraction is selectively inhibited by soluble ephrin-B receptor. This inhibition could be blocked by a truncated Pdz-Rgs3 protein lacking the RGS domain.
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